Peptides, from first principles
What a peptide is, what it is not, why almost all of them need a needle, and the evidence grade behind each category.
Protocol Index — health and performance protocols, graded on the evidence
Primers
The background every entry assumes. No protocols, no doses, no promises.
Choosing what to run
Pick one goal, match it to a category, and set out in advance what would count as it working.
What can go wrong
Side effects worth expecting, risks worth taking seriously, who should not start at all, and the symptoms that mean stop now.
Doing the arithmetic
Reconstitution, concentration and injection volume. The maths is simple; the unit errors are not forgiving.
Reconstituting a vial
Why it arrives as powder, what you need, the procedure step by step, and the handling mistakes that ruin a vial.
Storage and stability
Why the powder is stable, the four things that degrade it, the two clocks that start when you add water, and per-compound handling.
Giving the injection
Subcutaneous technique, where to site it, needle choice, rotation, and what is normal afterwards.
The nasal route
Which compounds actually absorb through the nose, which need a needle, and why “absorbs” and “works” are two different questions.
Compounds
One entry per compound: what the trials found, what is still unknown, and the grade behind each claim.
Retatrutide
A triple agonist with the largest weight-loss numbers ever recorded in an obesity trial — and no approval, no licensed supply, and no long-term data.
The protocol index
Separately: non-pharmacological protocols — training, sleep, diet — graded on the same rubric.
Four gates. Most protocols fail at two.
How an entry earns its place in the index — and how it loses it.
Gate 01
Claim, isolated
We write the claim as a testable sentence with a population, a dose, and an outcome. Vague promises are rejected here and never reach the index.
Gate 02
Evidence, weighed
Human trials first, then cohorts, then mechanism. We record sample size, funder, and whether anyone replicated it — including when nobody did.
Gate 03
Cost, counted
Hours per week, money per month, and the side effects that show up in the trial arms. A protocol that works but nobody sustains is marked as such.
Gate 04
Graded, then re-graded
Every entry carries a review date. When new trials land the grade moves — up or down — and the change is logged in the open changelog.